Synthesis and kinetic resolution of directional isomers of [2]rotaxanes bearing a lariat crown ether wheel

Rotaxanes can have topological isomers because of their mechanically interlocked axle and wheel components. Directional are formed when the rotaxanes constructed using an asymmetric a three-dimensional non-symmetrical wheel. In this work, directional [2]rotaxanes were synthesised lariat dibenzo-24-crown-8 ether as component sec-ammonium salt axle. Control over isomer ratio was achieved, demonstrated by kinetic resolution via N-acetylation [2]rotaxanes.